Is osteoarthritis a true connective tissue disorder or just joint degeneration over time?

2 Comments

1. JDC says:

   August 30, 2009 at 3:24 pm

   OA is a chronic degenerative disorder related to but not caused by aging, as there are people well into their nineties who have no clinical or functional signs of the disease. As a person ages, the water content of the cartilage decreases due to a reduced proteoglycan content, thus causing the cartilage to be less resilient. Without the protective effects of the proteoglycans, the collagen fibers of the cartilage can become susceptible to degradation and thus exacerbate the degeneration. Inflammation of the surrounding joint capsule can also occur, though often mild (compared to that which occurs in rheumatoid arthritis). This can happen as breakdown products from the cartilage are released into the synovial space, and the cells lining the joint attempt to remove them. New bone outgrowths, called "spurs" or osteophytes, can form on the margins of the joints, possibly in an attempt to improve the congruence of the articular cartilage surfaces. These bone changes, together with the inflammation, can be both painful and debilitating.

   So it a combination of them both, with the loss of the cartilage leading to the degeneration of the joints over time.
2. Doc2 says:

   August 30, 2009 at 3:24 pm

   Wear and tear on a joint with aging.